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The Proceedings of the American Thoracic Society 1:62-65 (2004)
© 2004 The American Thoracic Society

Effect of Inflammatory Stimuli on Airway Ion Transport

Luis J. V. Galietta, Chiara Folli, Emanuela Caci, Nicoletta Pedemonte, Alessandro Taddei, Roberto Ravazzolo and Olga Zegarra-Moran

Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genoa, Italy

Correspondence and requests for reprints should be addressed to Luis J. V. Galietta, Ph.D., Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Largo Gerolamo Gaslini, 5, 16148 Genoa, Italy. E-mail: galietta{at}unige.it

The airway epithelium controls the chemical and physical properties of airway surface fluid and consequently mucociliary clearance. The treatment for 24–48 hours of human bronchial epithelial cells with interferon-{gamma} or interleukin-4 leads to marked changes in transepithelial ion transport properties. Both cytokines downregulate the activity of the epithelial Na+ channel and, at the same time, upregulate Ca2+-dependent Cl- secretion. Interleukin-4 also increases the expression and function of the cystic fibrosis transmembrane conductance regulator Cl- channel. These results suggest that some inflammatory stimuli may change the balance between fluid absorption and secretion to favor hydration of the airway surface and consequently mucus clearance.

Key Words: airway epithelium • interferon-{gamma} • interleukin-4 • ion transport • mucociliary clearance




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