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© 2004 The American Thoracic Society
Mechanisms of Bronchial Hyperreactivity in Asthma and Chronic Obstructive Pulmonary Disease
Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
Correspondence and requests for reprints should be addressed to Diana C. Grootendorst, Ph.D., Leiden University Medical Centre, Department of Pulmonology C3-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands. E-mail: d.c.grootendorst{at}lumc.nl
Bronchial hyperreactivity has long been recognized as a hallmark of chronic asthma. Less is known about the prevalence and mechanisms of hyperreactivity in chronic obstructive pulmonary disease (COPD). Currently, it is unclear whether the role and mechanisms of hyperreactivity are similar in patients with asthma and COPD or whether the underlying pathophysiologic abnormalities are different for both diseases. The aim of this review is to present an overview of current knowledge of the mechanisms of bronchial hyperreactivity in asthma and COPD.
Key Words: asthma • chronic obstructive pulmonary disease • airway hyperresponsiveness • inflammation • human airway smooth muscle
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