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The Proceedings of the American Thoracic Society 2:68-70 (2005)
© 2005 The American Thoracic Society

Pulmonary Vascular Responses to Chronic Hypoxia Mediated by Hypoxia-inducible Factor 1

Gregg L. Semenza

Program in Vascular Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland

Correspondence and requests for reprints should be addressed to Gregg L. Semenza, M.D., Ph.D., Program in Vascular Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Suite 671, Baltimore, MD 21205. E-mail: gsemenza{at}jhmi.edu

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.

Key Words: gene expression • oxygen sensing • pulmonary hypertension




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