Proceedings of the American Thoracic Society Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matthay, M. A.
Right arrow Articles by Fang, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matthay, M. A.
Right arrow Articles by Fang, X.
The Proceedings of the American Thoracic Society 2:206-213 (2005)
© 2005 The American Thoracic Society

Alveolar Epithelium

Role in Lung Fluid Balance and Acute Lung Injury

Michael A. Matthay, Laurent Robriquet and Xiaohui Fang

Cardiovascular Research Institute, University of California–San Francisco, San Francisco, California

Correspondence and requests for reprints should be addressed to Michael A. Matthay, M.D., 505 Parnassus Avenue, M-917, San Francisco, CA 94143-0624. E-mail: mmatt{at}itsa.ucsf.edu

ABSTRACT

The resolution of alveolar edema is regulated by active sodium and chloride transport across the pulmonary epithelium, including alveolar epithelial type I and II cells as well as distal airway epithelia. Catecholamine-dependent mechanisms can markedly upregulate alveolar fluid clearance even under pathological conditions, an effect that is mediated by both epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR). Under pathological conditions, impaired alveolar fluid clearance is associated with worse survival in patients with acute lung injury. However, there is some experimental and clinical evidence that cAMP stimulation could accelerate the resolution of pulmonary edema in the presence of acute lung injury. Clinical trials are needed to test this potential therapeutic strategy in patients with acute lung injury.

Key Words: pulmonary edema • acute respiratory distress syndrome • alveolar fluid clearance • cystic fibrosis




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Casiraghi, J. R. Tatreau, J. B. Abano, J. W. Blackwell, L. Watson, K. Burridge, S. H. Randell, and T. M. Egan
In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation
J. Thorac. Cardiovasc. Surg., September 1, 2009; 138(3): 760 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Zanotti, M. Casiraghi, J. B. Abano, J. R. Tatreau, M. Sevala, H. Berlin, S. Smyth, W. K. Funkhouser, K. Burridge, S. H. Randell, et al.
Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema
Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L52 - L63.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. DeMaio, W. Tseng, Z. Balverde, J. R. Alvarez, K.-J. Kim, D. G. Kelley, R. M. Senior, E. D. Crandall, and Z. Borok
Characterization of mouse alveolar epithelial cell monolayers
Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L1051 - L1058.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H.-G. Nie, T. Tucker, X.-F. Su, T. Na, J.-B. Peng, P. R. Smith, S. Idell, and H.-L. Ji
Expression and Regulation of Epithelial Na+ Channels by Nucleotides in Pleural Mesothelial Cells
Am. J. Respir. Cell Mol. Biol., May 1, 2009; 40(5): 543 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. P. Comellas, A. Briva, L. A. Dada, M. L. Butti, H. E. Trejo, C. Yshii, Z. S. Azzam, J. Litvan, J. Chen, E. Lecuona, et al.
Endothelin-1 Impairs Alveolar Epithelial Function via Endothelial ETB Receptor
Am. J. Respir. Crit. Care Med., January 15, 2009; 179(2): 113 - 122.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Bhalla and K. R. Hallows
Mechanisms of ENaC Regulation and Clinical Implications
J. Am. Soc. Nephrol., October 1, 2008; 19(10): 1845 - 1854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. F. Bao, L. Liu, J. Self, B. J. Duke, R. Ueno, and D. C. Eaton
A synthetic prostone activates apical chloride channels in A6 epithelial cells
Am J Physiol Gastrointest Liver Physiol, August 1, 2008; 295(2): G234 - G251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. S. Rogers, W. M. Abraham, K. A. Brogden, J. F. Engelhardt, J. T. Fisher, P. B. McCray Jr., G. McLennan, D. K. Meyerholz, E. Namati, L. S. Ostedgaard, et al.
The porcine lung as a potential model for cystic fibrosis
Am J Physiol Lung Cell Mol Physiol, August 1, 2008; 295(2): L240 - L263.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
V. Shlyonsky, A. Goolaerts, F. Mies, and R. Naeije
Electrophysiological Characterization of Rat Type II Pneumocytes in Situ
Am. J. Respir. Cell Mol. Biol., July 1, 2008; 39(1): 36 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. A. Carey, J. W. Card, J. W. Voltz, D. R. Germolec, K. S. Korach, and D. C. Zeldin
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L272 - L278.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Thoracic Society. 		 
Tobacco