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The Proceedings of the American Thoracic Society 2:373-385 (2005)
© 2005 The American Thoracic Society

Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease

Caroline A. Owen

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Caroline Owen, M.D., Ph.D., Division of Pulmonary and Critical Care Medicine, 905 Thorn Building, Brigham and Women's Hospital, Boston, MA 02115. E-mail: cowen{at}rics.bwh.harvard.edu

There is now compelling evidence that proteinases and oxidative stress play pathogenetic roles in the following pathologies in chronic obstructive pulmonary disease: airspace enlargement; chronic inflammation in the airways, lung interstitium, and alveolar space; and mucus hypersecretion in the large airways. Proteinases and oxidants may also contribute to remodeling processes in the small airways. In addition, data are emerging that show interactions between classes of proteinases and between proteinases and oxidants, which amplify lung inflammation and injury in chronic obstructive pulmonary disease. This review discusses the biologic roles of proteinases and oxidants, their roles in the pathogenesis of chronic obstructive pulmonary disease, and their potential as targets for therapy.

Key Words: antiinflammatory drugs • antioxidants • oxidative stress • proteinase inhibition • proteinases




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