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Computed Tomography Studies of Lung Ventilation and Perfusion

Departments of Radiology and Biomedical Engineering, University of Iowa, Iowa City, Iowa

Correspondence and requests for reprints should be addressed to Eric A. Hoffman, Ph.D., Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52240. E-mail: eric-hoffman{at}uiowa.edu

ABSTRACT

With the emergence of multidetector-row computed tomography (CT) it is now possible to image both structure and function via use of a single imaging modality. Breath-hold spiral CT provides detail of the airway and vascular trees along with texture reflective of the state of the lung parenchyma. Use of stable xenon gas wash-in and/or wash-out methods using an axial mode of the CT scanner whereby images are acquired through gating to the respiratory cycle provide detailed images of regional ventilation with isotropic voxel dimensions now on the order of 0.4 mm. Axial scanning during a breath hold and gating to the electrocardiogram during the passage of a sharp bolus injection of iodinated contrast agent provide detailed images of regional pulmonary perfusion. These dynamic CT methods for the study of regional lung function are discussed in the context of other methods that have been used to study heterogeneity of lung function.

Key Words: computed tomography, functional, quantitative, xenon • pulmonary blood flow • pulmonary perfusion • pulmonary ventilation

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Proceedings of the American Thoracic Society 2005 2: 499-516. [Full Text]  

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