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The Proceedings of the American Thoracic Society 2:517-521 (2005)
© 2005 The American Thoracic Society

Computed Tomography Studies of Lung Mechanics

Brett A. Simon, Gary E. Christensen, Daniel A. Low and Joseph M. Reinhardt

Department of Anesthesiology/Critical Care Medicine and Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Departments of Electrical and Computer Engineering and Biomedical Engineering, University of Iowa, Iowa City, Iowa; and Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Correspondence and requests for reprints should be addressed to Brett A. Simon, M.D., Ph.D., Department of Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-8711. E-mail: bsimon{at}jhmi.edu

ABSTRACT

The study of lung mechanics has progressed from global descriptions of lung pressure and volume relationships to the high-resolution, three-dimensional, quantitative measurement of dynamic regional mechanical properties and displacements. X-ray computed tomography (CT) imaging is ideally suited to the study of regional lung mechanics in intact subjects because of its high spatial and temporal resolution, correlation of functional data with anatomic detail, increasing volumetric data acquisition, and the unique relationship between CT density and lung air content. This review presents an overview of CT measurement principles and limitations for the study of regional mechanics, reviews some of the early work that set the stage for modern imaging approaches and impacted the understanding and management of patients with acute lung injury, and presents evolving novel approaches for the analysis and application of dynamic volumetric lung image data.

Key Words: computed tomography • mathematical modeling • physiology


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