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Bioluminescence Imaging

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, and Departments of Cell and Developmental Biology and Cancer Biology, Vanderbilt University School of Medicine; and Department of Veterans Affairs, Nashville, Tennessee

Correspondence and requests for reprints should be addressed to Timothy S. Blackwell, M.D., Vanderbilt University School of Medicine, T-1218 MCN, Nashville, TN 37232-2650. E-mail: timothy.blackwell{at}vanderbilt.edu

ABSTRACT

Bioluminescence refers to the process of visible light emission in living organisms. Bioluminescence imaging is a powerful methodology that has been developed over the last decade as a tool for molecular imaging of small laboratory animals, enabling the study of ongoing biological processes in vivo. This form of optical imaging is low cost and noninvasive and facilitates real-time analysis of disease processes at the molecular level in living organisms. In this article, we provide a brief introduction to bioluminescence imaging technology and discuss its applications in mouse models of lung inflammation/injury, bacterial pneumonia, and tumor growth and metastasis.

Key Words: nuclear factor kappa B • lung • endotoxin • pneumonia • cancer

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Proceedings of the American Thoracic Society 2005 2: 499-516. [Full Text]  

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