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The Proceedings of the American Thoracic Society 2:549-552 (2005)
© 2005 The American Thoracic Society

Molecular Imaging of Pulmonary Gene Expression with Positron Emission Tomography

Sekhar Dharmarajan and Daniel P. Schuster

Departments of Surgery, Medicine, and Radiology, Washington University School of Medicine, St. Louis, Missouri

Correspondence and requests for reprints should be addressed to Daniel P. Schuster, M.D., University Box 8225, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: daniel.schuster{at}wustl.edu

ABSTRACT

Gene expression imaging is one form of molecular imaging used to visualize, characterize, and quantify, spatially and temporally, normal as well as pathologic processes at cellular and subcellular levels within intact living organisms. Most studies to date have employed positron emission tomography as the imaging platform to detect, monitor, and quantify gene expression in the lungs. These studies have shown that imaging can be used to determine the onset and duration of transgene expression, the effectiveness of different gene delivery systems, and the linearity of vector dose–response relationships. This rapidly developing field can be expected to provide useful new tools with which to study gene expression in transgenic animals and in humans during gene therapy.

Key Words: FHGB • gene reporters • thymidine kinase


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Proceedings of the American Thoracic Society 2005 2: 499-516. [Full Text]  





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