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Chronic Obstructive Pulmonary Disease

From Unjustified Nihilism to Evidence-based Optimism

Department of Medicine, Tufts University; and Pulmonary and Critical Care Division, St. Elizabeth's Medical Center, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Bartolome R. Celli, M.D., Pulmonary and Critical Care Division, St. Elizabeth's Medical Center, Boston, MA 02135. E-mail: bcelli{at}cchcs.org, bcelli@copdnet.org, bcelli@semc.org

ABSTRACT

Chronic obstructive pulmonary disease (COPD) has been associated with a nihilistic attitude. On the basis of current evidence, this nihilistic attitude is totally unjustified. The disease must be viewed through the lens of a new paradigm: one that accepts COPD as not only a pulmonary disease but also as one with important measurable systemic consequences. COPD is not only preventable but also treatable. Smoking cessation, oxygen for hypoxemic patients, lung reduction surgery for selected patients with emphysema, and noninvasive ventilation during severe exacerbations have all been shown to impact on mortality. In addition, pulmonary rehabilitation, pharmacologic therapy, and lung transplantation improve patient-centered outcomes such as health-related quality of life, dyspnea, exercise capacity, and even exacerbations and hospitalizations. Caregivers should familiarize themselves with the multiple complementary forms of treatment and individualize therapy to the particular situation of each patient. The future for patients with this disease is bright as its pathogenesis and clinical and phenotypic manifestations are unraveled. The advent of newer and more effective therapies will lead to a decline in the contribution of this disease to poor world health.

Key Words: airflow obstruction • bronchitis • chronic obstructive pulmonary disease • emphysema

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