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The Proceedings of the American Thoracic Society 3:405-408 (2006)
© 2006 The American Thoracic Society

Progress in Chronic Obstructive Pulmonary Disease Genetics

Edwin K. Silverman

Channing Laboratory and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Edwin K. Silverman, M.D., Ph.D., Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. E-mail: ed.silverman{at}channing.harvard.edu

ABSTRACT

Familial aggregation of chronic obstructive pulmonary disease (COPD) has been demonstrated, suggesting that genetic factors likely influence the variable development of chronic airflow obstruction in response to smoking. A variety of approaches have been used to identify novel COPD susceptibility genes, including association studies, linkage analysis, and rare variant analysis. Future directions for COPD research include genomewide association studies and animal model genetic studies.

Key Words: association analysis • chronic obstructive pulmonary disease • genetics • linkage analysis




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