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Genetics of Sarcoidosis

Candidate Genes and Genome Scans

Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, New York; and Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan

Correspondence and requests for reprints should be addressed to Michael C. Iannuzzi, M.D., M.B.A., 1 Gustave Levy Place, Box 1232, New York, NY 10029. E-mail: michael.iannuzzi{at}mssm.edu

ABSTRACT

Human leukocyte antigen class II allele associations and T-cell receptor beta chain bias in sarcoidosis suggest a specific disease-triggering antigen exposure in a genetically susceptible host. The cause of sarcoidosis has been elusive, but genetics provides one of the few promising avenues to further our understanding. We review the association studies and genome scans used to identify the genes involved in sarcoidosis.

Key Words: sarcoidosis • genetics • genomics

This article has been cited by other articles:

				M. C. Iannuzzi, B. A. Rybicki, and A. S. Teirstein Sarcoidosis N. Engl. J. Med., November 22, 2007; 357(21): 2153 - 2165. [Full Text] [PDF]