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Gene Expression Profiling in Pulmonary Hypertension

Pulmonary and Critical Care Medicine Division, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, Colorado

Correspondence and requests for reprints should be addressed to Mark W. Geraci, M.D., Division of Pulmonary Sciences and Critical Care Medicine, Gene Expression Facility, UCDHSC, 4200 East Ninth Avenue, Campus Box C-272, Denver, CO 80262. E-mail: mark.geraci{at}uchsc.edu

ABSTRACT

The application of functional genomics toward the investigation of complex medical conditions has moved from a futuristic dream to a medical reality in less then a decade. The ability to examine the expression level of thousands of genes simultaneously has opened the door for entirely new approaches toward experimental observation and discovery. The resulting data from these genomic studies is being collected at an unprecedented scale. This wealth of data can present its own obstacles in terms of analysis. However, as new and more powerful means of examining these experiments are developed, medical science is reaping significant benefit. The power of microarray gene expression analysis has been directed at a diverse and complex array of diseases. As will be discussed in this article, the investigation of pulmonary hypertension has already benefited greatly from the application of this technology.

Key Words: gene expression profiling • pulmonary hypertension • gene microarray • pulmonary vascular disease

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