HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cook, D. N. Articles by Bottomly, K. Search for Related Content PubMed PubMed Citation Articles by Cook, D. N. Articles by Bottomly, K.

Innate Immune Control of Pulmonary Dendritic Cell Trafficking

¹ Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina; ² Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut

Correspondence and requests for reprints should be addressed to Donald N. Cook, Ph.D., Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Building 101, E244, Research Triangle Park, NC 27709. E-mail cookd{at}niehs.nih.gov

ABSTRACT

Dendritic cells (DC) are potent antigen-presenting cells that are essential for initiating adaptive immune responses. Residing within the airway mucosa, pulmonary DC continually sample the antigenic content of inhaled air and migrate to draining lymph nodes, where they present these antigens to naive T cells. The migratory patterns of pulmonary DC are highly dependent upon inflammatory conditions in the lung. Under steady-state, or non-inflammatory, conditions, pulmonary DC undergo slow but constitutive migration to draining lymph nodes, where they remain for several days and confer antigen-specific tolerance. With the onset of pulmonary inflammation, airway DC trafficking increases dramatically, and these cells rapidly accumulate within draining lymph nodes. However, within a few days, the number of airway-derived DC in lymph nodes stabilizes or declines, even in the face of ongoing pulmonary inflammation. Here, we summarize current understanding of the molecular and cellular mechanisms underlying pulmonary DC trafficking to the lymph node and the recruitment of DC precurors to the lung. It is hoped that an improved understanding of these mechanisms will lead to novel DC-mediated therapeutic strategies to treat immune-related pulmonary disease.

Key Words: lung • dendritic cells • lymph nodes

This article has been cited by other articles:

				T. Sun, R. L. Surles, and S. A. Tanumihardjo Vitamin A Concentrations in Piglet Extrahepatic Tissues Respond Differently Ten Days after Vitamin A Treatment J. Nutr., June 1, 2008; 138(6): 1101 - 1106. [Abstract] [Full Text] [PDF]

				C. Jakubzick, F. Tacke, F. Ginhoux, A. J. Wagers, N. van Rooijen, M. Mack, M. Merad, and G. J. Randolph Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations J. Immunol., March 1, 2008; 180(5): 3019 - 3027. [Abstract] [Full Text] [PDF]