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© 2007 The American Thoracic Society
doi: 10.1513/pats.200701-018AW
Immunomodulatory Roles of Surfactant Proteins A and D
Implications in Lung Disease
1 Department of Cell Biology, 2 Division of Physical Therapy, Department of Community and Family Medicine, and 3 Department of Immunology, Duke University Medical Center, Durham, North Carolina
Correspondence and requests for reprints should be addressed to Kristi L. Williams, Ph.D., Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710. E-mail: klw{at}cellbio.duke.edu
ABSTRACT
Surfactant, a lipoprotein complex, was originally described for its essential role in reducing surface tension at the air–liquid interface of the lung; however, it is now recognized as being a critical component in lung immune host defense. Surfactant proteins (SP)-A and -D are pattern recognition molecules of the collectin family of C-type lectins. SP-A and SP-D are part of the innate immune system and regulate the functions of other innate immune cells, such as macrophages. They also modulate the adaptive immune response by interacting with antigen-presenting cells and T cells, thereby linking innate and adaptive immunity. Emerging studies suggest that SP-A and SP-D function to modulate the immunologic environment of the lung so as to protect the host and, at the same time, modulate an overzealous inflammatory response that could potentially damage the lung and impair gas exchange. Numerous polymorphisms of SPs have been identified that may potentially possess differential functional abilities and may act via different receptors to ultimately alter the susceptibility to or severity of lung diseases.
Key Words: collectins • innate immunity • lung disease
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