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Chest Radiographs for Outcome Assessment in Cystic Fibrosis

Robert H. Cleveland¹, David Zurakowski², Dubhfeasa M. Slattery^3, and Andrew A. Colin^3,*

¹ Department of Radiology, ² Departments of Orthopaedic Surgery and Biostatistics, and ³ Division of Pulmonary Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Robert H. Cleveland, M.D., Department of Radiology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115. E-mail: Robert.Cleveland{at}childrens.harvard.edu

ABSTRACT

We compare a chest radiographic scoring system developed by our group to spirometry in quantifying the longitudinal progression of lung disease among cystic fibrosis (CF) patients, and we evaluate the use of this radiographic scoring system in identifying the treatment effect of an inhaled antibiotic. Results suggest that longitudinally acquired chest radiographs, when scored using our scoring system, are at least as sensitive as lung function in detecting the progression of lung disease in CF patients.

Key Words: chest radiograph • cystic fibrosis