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Computed Tomography Scanning in Cystic Fibrosis Research Trials

Practical Lessons from Three Clinical Trials in the United States

¹ Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio

Correspondence and requests for reprints should be addressed to Alan S. Brody, M.D., Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229-3039. E-mail: alan.brody{at}cchmc.org

ABSTRACT

Over the last 15 years, several clinical trials in subjects with cystic fibrosis (CF) have employed computed tomography (CT) scanning as an outcome surrogate. These research trials have increased our knowledge about the appearance of the lungs in patients with CF, and the relationship between the CT appearance, pulmonary function tests, and clinical outcomes. In addition, practical information has been gained on the use of CT scanning in CF research trials. In this article, practical issues on the use of CT scanning in CF clinical trials are presented and specific lessons from three of these trials are discussed.

Key Words: clinical trial • surrogate endpoint • diagnostic imaging • high-resolution computed tomography

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