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The Proceedings of the American Thoracic Society 4:567-569 (2007)
© 2007 The American Thoracic Society
doi: 10.1513/pats.200707-099JK
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Selection of Controls in Clinical Trials

Introduction and Conference Summary

David H. Au1,2,*, Mario Castro3,* and Jerry A. Krishnan4,5,*

1 Health Services Research and Development, VA Puget Sound Health Care System, Seattle, Washington; 2 Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington; 3 Division of Pulmonary and Critical Care Medicine, Washington University, St. Louis, Missouri; and 4 Section of Pulmonary and Critical Care, Department of Medicine, and 5 Department of Health Studies, University of Chicago, Chicago, Illinois

Correspondence and requests for reprints should be addressed to Jerry A. Krishnan, M.D., Ph.D., Associate Professor of Medicine and Health Studies (Epidemiology), Director, Asthma Center, Section of Pulmonary and Critical Care Medicine, University of Chicago, 5841 South Maryland Avenue, MC 6076, Chicago, IL 60637. E-mail: jkrishna{at}bsdad.uchicago.edu

ABSTRACT

Understanding the strengths and weaknesses of the control group used in a randomized clinical trial is essential because comparisons of outcomes between the investigational and control groups form the basis of inferences regarding the safety and efficacy of the investigational treatment. For its 2007 International Conference, the American Thoracic Society (ATS) sponsored a scientific symposium in which the strengths and limitations of different types of control groups in clinical trials of pharmacotherapy, procedures, devices, and behavioral interventions were discussed. In this section, the co-chairs of this ATS symposium provide an overview of the presentations, including a brief historical perspective on the use of control groups in clinical trials.

Key Words: clinical trials • control groups • ethics






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