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The Proceedings of the American Thoracic Society 4:626-634 (2007)
© 2007 The American Thoracic Society
doi: 10.1513/pats.200706-071TH
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Systemic Inflammation in Chronic Obstructive Pulmonary Disease

The Role of Exacerbations

Emiel F. M. Wouters1, Karin H. Groenewegen1, Mieke A. Dentener1 and Juanita H. J. Vernooy1

1 Department of Respiratory Medicine, University Hospital Maastricht, Maastrict, The Netherlands

Correspondence and requests for reprints should be addressed to Prof.dr. E. F. M. Wouters, Department of Respiratory Medicine, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. E-mail: e.wouters{at}lung.azm.nl

ABSTRACT

The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal studies. Most of the systemic manifestations are likely the result of inflammatory processes. Serum biomarkers, such as various cytokines, adipokines, C-reactive protein, and coagulation factors, are elevated during exacerbations. Our understanding of the systemic manifestations can be greatly enhanced if we integrate what is known about the basic science of systemic mediators with the translational science of their role in COPD exacerbations. Many overlapping connections and promising avenues of future research come to light with such a viewpoint.

Key Words: systemic inflammation • COPD, exacerbation • C-reactive protein




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