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The Proceedings of the American Thoracic Society 5:11-14 (2008)
© 2008 The American Thoracic Society
doi: 10.1513/pats.200704-052VS
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Stem Cells in Airway Smooth Muscle

State of the Art

Jaime Murphy1, Ross Summer1 and Alan Fine1

1 The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Jaime Murphy, M.D., The Pulmonary Center, R-304, 715 Albany Street, Boston University School of Medicine, Boston, MA 02118. E-mail: murphj04{at}bu.edu

ABSTRACT

Very little is known regarding the function, origin, and turnover of airway smooth muscle (ASM). In this article, we discuss the embryological development of ASM, and provide information regarding candidate mesenchymal ASM progenitor cell populations specifically in relation to airway remodeling. This review also highlights the current limitations in studying ASM biology, and underscores the need for novel molecular tools and markers that will refine our understanding of this cell type in lung homeostasis and disease.

Key Words: stem cells • smooth muscle • progenitor cells • fibrocyte • myofibroblast




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D. J. Weiss, J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Proceedings of the ATS, July 15, 2008; 5(5): 637 - 667.
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