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Regulation of Heterotrimeric G Protein Signaling in Airway Smooth Muscle

¹ Department of Internal Medicine, Center for Human Genomics, Wake Forest University Health Sciences, Winston-Salem, North Carolina; and ² Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania

Correspondence and requests for reprints should be addressed to Raymond B. Penn, Ph.D., Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157. E-mail: rpenn{at}wfubmc.edu

ABSTRACT

Heterotrimeric G proteins transduce signals from G protein–coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.

Key Words: G protein–coupled receptor • RGS protein • airway remodeling • inflammation • bronchospasm

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