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The Proceedings of the American Thoracic Society 5:89-96 (2008)
© 2008 The American Thoracic Society
doi: 10.1513/pats.200705-063VS
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Airway Smooth Muscle Growth in Asthma

Proliferation, Hypertrophy, and Migration

J. Kelley Bentley1 and Marc B. Hershenson1,2

1 Department of Pediatrics and Communicable Diseases and 2 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan

Correspondence and requests for reprints should be addressed to Marc B. Hershenson, M.D., University of Michigan, Medical Science Research Building II, 1150 W. Medical Center Drive, Room 3570B, Ann Arbor, MI 48109-0688. E-mail: mhershen{at}umich.edu

ABSTRACT

Increased airway smooth muscle mass is present in fatal and non-fatal asthma. However, little information is available regarding the cellular mechanism (i.e., hyperplasia vs. hypertrophy). Even less information exists regarding the functional consequences of airway smooth muscle remodeling. It would appear that increased airway smooth muscle mass would tend to increase airway narrowing and airflow obstruction. However, the precise effects of increased airway smooth muscle mass on airway narrowing are not known. This review will consider the evidence for airway smooth muscle cell proliferation and hypertrophy in asthma, potential functional effects, and biochemical mechanisms.

Key Words: {alpha}-smooth muscle actin • hyperresponsiveness • translational control • migration




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