Proceedings of the American Thoracic Society Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Proceedings of the American Thoracic Society 5:89-96 (2008)
© 2008 The American Thoracic Society
doi: 10.1513/pats.200705-063VS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bentley, J. K.
Right arrow Articles by Hershenson, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bentley, J. K.
Right arrow Articles by Hershenson, M. B.

Airway Smooth Muscle Growth in Asthma

Proliferation, Hypertrophy, and Migration

J. Kelley Bentley1 and Marc B. Hershenson1,2

1 Department of Pediatrics and Communicable Diseases and 2 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan

Correspondence and requests for reprints should be addressed to Marc B. Hershenson, M.D., University of Michigan, Medical Science Research Building II, 1150 W. Medical Center Drive, Room 3570B, Ann Arbor, MI 48109-0688. E-mail: mhershen{at}umich.edu

ABSTRACT

Increased airway smooth muscle mass is present in fatal and non-fatal asthma. However, little information is available regarding the cellular mechanism (i.e., hyperplasia vs. hypertrophy). Even less information exists regarding the functional consequences of airway smooth muscle remodeling. It would appear that increased airway smooth muscle mass would tend to increase airway narrowing and airflow obstruction. However, the precise effects of increased airway smooth muscle mass on airway narrowing are not known. This review will consider the evidence for airway smooth muscle cell proliferation and hypertrophy in asthma, potential functional effects, and biochemical mechanisms.

Key Words: {alpha}-smooth muscle actin • hyperresponsiveness • translational control • migration




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. K. Malavia, C. B. Raub, S. B. Mahon, M. Brenner, R. A. Panettieri Jr., and S. C. George
Airway Epithelium Stimulates Smooth Muscle Proliferation
Am. J. Respir. Cell Mol. Biol., September 1, 2009; 41(3): 297 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. J. Saude, I. P. Obiefuna, R. L. Somorjai, F. Ajamian, C. Skappak, T. Ahmad, B. K. Dolenko, B. D. Sykes, R. Moqbel, and D. J. Adamko
Metabolomic Biomarkers in a Model of Asthma Exacerbation: Urine Nuclear Magnetic Resonance
Am. J. Respir. Crit. Care Med., January 1, 2009; 179(1): 25 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. Wu, Y. Huang, B. P. Herring, and S. J. Gunst
Integrin-linked kinase regulates smooth muscle differentiation marker gene expression in airway tissue
Am J Physiol Lung Cell Mol Physiol, December 1, 2008; 295(6): L988 - L997.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Sevilla-Perez, M. Konigshoff, G. Kwapiszewska, O. V. Amarie, W. Seeger, N. Weissmann, R. T. Schermuly, R. E. Morty, and O. Eickelberg
Shroom expression is attenuated in pulmonary arterial hypertension
Eur. Respir. J., October 1, 2008; 32(4): 871 - 880.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Thoracic Society. 		 
CCM abstracts