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The Proceedings of the American Thoracic Society 5:161-172 (2008)
© 2008 The American Thoracic Society
doi: 10.1513/pats.200709-150MG
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Positive Pressure Therapy

A Perspective on Evidence-based Outcomes and Methods of Application

Mark H. Sanders1, Josep M. Montserrat2, Ramon Farré3,4 and Rachel J. Givelber1

1 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; 2 Sleep Laboratory, Hospital Clínic–Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), and Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Bunyola, Spain; and 3 Unitat Biofisica i Bioenginyeria, Facultat de Medicina, Universitat Barcelona-IDIBAPS, Barcelona, Spain; and 4 CIBER Enfermedades Respiratorias, Bunyola, Spain

Correspondence and requests for reprints should be addressed to Mark H. Sanders, M.D., Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Avenue, Suite S-639.11, Pittsburgh, PA 15213. E-mail: sandersmh{at}upmc.edu

ABSTRACT

The sleep medicine community has increasingly recognized the necessity that clinical care be based on high-quality levels of evidence. Although research supports a favorable influence of positive airway pressure (PAP) therapy on risk for significant adverse outcomes in patients with severe obstructive sleep apnea–hypopnea (OSAH), well-designed trials are still required to elucidate the effect of PAP on health, quality of life, and economic risks in patients with milder OSAH. Similarly, although there is strong evidence supporting various PAP titration strategies and PAP modalities in patients with severe OSAH without significant medical and psychiatric comorbidities, there is insufficient high-level evidence assessing and comparing the clinical efficacy and health care cost implications of various titration paradigms and various PAP modalities in individuals with milder OSAH and those with comorbid conditions. For ethical and other reasons, it may not be possible to apply a randomized controlled design to address all questions. However, whichever design is employed, it must be rigorously developed with attention to all potential confounders with adequate power to provide compelling, high-quality evidence.

Key Words: obstructive sleep apnea • positive airway pressure • therapy of sleep apnea






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