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National Emphysema Treatment Trial

The Major Outcomes of Lung Volume Reduction Surgery in Severe Emphysema

¹ Temple University School of Medicine, Philadelphia, Pennsylvania; and ² Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland

Correspondence and requests for reprints should be addressed to Gerard J. Criner, M.D., Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, 745 Parkinson Pavilion, 3401 North Broad Street, Philadelphia, PA 19140. E-mail: crinerg{at}tuhs.temple.edu

ABSTRACT

The National Emphysema Treatment Trial (NETT) has published many articles reporting the various outcomes of lung volume reduction surgery versus medical treatment for patients with severe emphysema. However, long and complex clinical trials like NETT that involve both medical and surgical issues generate multiple manuscripts over a period of years and report an array of various outcomes. As a result, the essential findings of the trial may appear to be fragmented to the clinician or clinical researcher or be lost among the many medical reports published each year. In this review, we summarize in one publication the major medical and surgical outcomes of NETT.

Key Words: emphysema • lung reduction • clinical trial