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Hierarchical Organization of Lung Progenitor Cells

Is there An Adult Lung Tissue Stem Cell?

¹ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina

Correspondence and requests for reprints should be addressed to Barry R. Stripp, Ph.D., Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, 2075 MSRBII, 106 Research Drive, DUMC Box 103000, Durham, NC 27710. E-mail: barry.stripp{at}duke.edu

ABSTRACT

Dynamic changes to the developing lung endoderm during the process of lung development result in the establishment of functionally distinct epithelial compartments that vary both in their cellular composition and mechanisms contributing to their maintenance in adulthood. This focused review compares the hierarchical organization of cells within slowly and rapidly renewing tissues as a basis to better understand cellular and molecular mechanisms regulating epithelial maintenance and repair in the lung.

Key Words: progenitor • stem cell • lung repair

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				J. C. Snyder, A. C. Zemke, and B. R. Stripp Reparative Capacity of Airway Epithelium Impacts Deposition and Remodeling of Extracellular Matrix Am. J. Respir. Cell Mol. Biol., June 1, 2009; 40(6): 633 - 642. [Abstract] [Full Text] [PDF]

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