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The Proceedings of the American Thoracic Society 5:707-710 (2008)
© 2008 The American Thoracic Society
doi: 10.1513/pats.200801-007AW
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Mesenchymal Progenitor Cell Research

Limitations and Recommendations

Ross Summer1 and Alan Fine1

1 The Pulmonary Center, Boston University, Boston, Massachusetts

Correspondence and requests for reprints should be addressed to Alan Fine, M.D., The Pulmonary Center, R-304, 715 Albany Street, Boston University School of Medicine, Boston, MA 02118-2394. E-mail: afine{at}bu.edu

ABSTRACT

There is considerable interest in mesenchymal stem cell biology. This relates, in part, to the possibility that such cells could be used to replace tissues in degenerative diseases of mesenchyme. In this article, the current status of the field is discussed, highlighting technical and theoretical issues related to the identification, isolation, and characterization of these cells. Our focus is the endogenous noncirculating mesenchymal stem cell populations that normally reside in adult organs.

Key Words: mesenchyme • stem cells • progenitor • lung






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