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© 2009 The American Thoracic Society
doi: 10.1513/pats.200810-116CB
Strategic Plan for Pediatric Respiratory Diseases Research
An NHLBI Working Group Report
1 Washington University School of Medicine, Medicine and Pediatrics, St. Louis, Missouri; 2 Boston University Medical, Boston, Maryland; 3 University of Wisconsin-Madison, Pediatrics, Madison, Wisconsin; 4 Johns Hopkins Medical Institutions, Baltimore, Maryland; 5 Children's Hospital and Regional Medical Center, Pulmonary Medicine, Seattle, Washington; 6 University of Alabama-Birmingham, Pediatrics, Cell Biology, Pathology and Biochemistry/Molecular Genetics, Birmingham, Alabama; 7 Cincinnati Children's Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, Cincinnati, Ohio; 8 University of Colorado School of Medicine and the Children's Hospital, Pediatrics, Denver, Colorado; 9 University of Illinois at Chicago, Pediatrics, Chicago, Illinois; 10 Columbia University, New York, New York; 11 NHLBI/NIH, Pulmonary and Vascular Medicine Branch, Bethesda, Maryland; 12 University of Louisville, Pediatrics, Louisville, Kentucky; 13 University of California, San Diego, California; 14 University of Chicago, Biology Science Division, Chicago, Illinois; 15 Johns Hopkins Medical Institutions, Pediatrics, Baltimore, Maryland; 16 University of Arizona College of Medicine Pediatrics, Tucson, Arizona; 17 Indiana University School of Medicine, Pediatrics, Indianapolis, Indiana; 18 Cincinnati Children's Hospital Medical Center, Pulmonary Medicine, Cincinnati, Ohio; 19 University of Colorado, Pulmonary Medicine/Cystic Fibrosis Center, Denver, Colorado; 20 Emory University, Pediatric Pulmonary Medicine, Atlanta, Georgia; 21 Massachusetts General, Department of Anesthesia/Critical, Boston, Massachusetts; 22 Washington University School of Medicine, Pediatrics, St. Louis, Missouri; and 23 Brigham & Women's Hospital, Boston, Massachusetts
Correspondence and requests for reprints should be addressed to Carol J. Blaisdell, M.D., Lung Developmental Biology and Pediatric Pulmonary Disease, Division of Lung Diseases, NHLBI/NIH, 6701 Rockledge Drive, 10042, Bethesda, MD 20892. E-mail: blaisdellcj{at}nhlbi.nih.gov
ABSTRACT
The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease; sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases; (2) injury, regeneration, and repair in the developing lung; (3) pulmonary vascular disease in children; (4) development and adaptation of ventilatory responses to postnatal life; (5) nonatopic wheezing: aberrant large airway development or injury?; (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases; and (7) predictive and personalized medicine for children.
Key Words: epigenetics • lung injury • pulmonary vascular disease • wheezing • ventilator control
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