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The Proceedings of the American Thoracic Society 6:249-255 (2009)
© 2009 The American Thoracic Society
doi: 10.1513/pats.200806-054RM
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Nuclear Factor {kappa}B, Airway Epithelium, and Asthma

Avenues for Redox Control

Yvonne M. W. Janssen-Heininger1, Matthew E. Poynter2, Scott W. Aesif1, Cristen Pantano1, Jennifer L. Ather1, Niki L. Reynaert3, Karina Ckless1, Vikas Anathy1, Jos van der Velden1, Charles G. Irvin2 and Albert van der Vliet1

Departments of 1 Pathology and 2 Medicine, University of Vermont College of Medicine, Burlington, Vermont; and the 3 Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands

Correspondence and requests for reprints should be addressed to Yvonne M. W. Janssen-Heininger, Ph.D., Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405. E-mail: yvonne.janssen{at}uvm.edu

ABSTRACT

A wealth of recent studies points to the importance of airway epithelial cells in the orchestration of inflammatory responses in the allergic inflamed lung. Studies also point to a role of oxidative stress in the pathophysiology of chronic inflammatory diseases. This article provides a perspective on the significance of airway epithelial cells in allergic inflammation, and reviews the relevance of the transcription factor, nuclear factor {kappa}B, herein. We also provide the reader with a perspective on the role that oxidants can play in lung homeostasis, and address the concept of "redox biology." In addition, we review recent evidence that highlights potential inhibitory roles of oxidants on nuclear factor {kappa}B activation and inflammation, and discuss recent assays that have become available to probe the functional roles of oxidants in lung biology.

Key Words: epithelium • nuclear factor {kappa}B • asthma • oxidants






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