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New Paradigms in the Pathogenesis of Chronic Obstructive Pulmonary Disease I

¹ University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom; and ² Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, Colorado

Correspondence and requests for reprints should be addressed to William MacNee, M.D., F.R.C.P., University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. E-mail: w.macnee{at}ed.ac.uk

ABSTRACT

This paper reviews the potential participation of novel pathogenic mechanisms in chronic obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and enhanced expression of markers of senescence in emphysematous lungs and the potential enhanced tissue destruction involving alveolar apoptosis. These insights provide new beginnings for future investigations in the pathobiology of COPD which may lead to future therapies for this condition.

Key Words: aging • oxidative stress • senescence • emphysema • apoptosis