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Abstracts Presented at the 49th Annual Meeting of the Thomas L. Petty Aspen Lung Conference

Identifying T Cell Ligands in Sarcoidosis. M. T. Falta, F. Crawford, A. Geluk, T. H. M. Ottenhoff, J. Grunewald, P. Marrack, J. W. Kappler, and A. P. Fontenot

A Murine Model of T Cell-Mediated Vasculitis. D. C. Baiu, B. Barger, B. J. Swanson, and M. N. Hart

Correlation of BAL Chemokines with Clinical Parameters in Scleroderma Lung Disease. M. P. Keane, J. Chung, W. Liu, R. Elashoff, J. A. Belperio, M. D. Roth, R. M. Silver, C. Strange, M. Sterz, P. J. Clements, D. E. Furst, D. A. Zisman, J. Goldin, M. D. Burdick, R. M. Strieter, and D. P. Tashkin, for the Scleroderma Lung Study Group

Silicosis Is a Chronic Innate Immune Response Driven by Macrophages and Natural Killer Cells. G. Davis, M. Poynter, E. Hsu, L. Pfeiffer, D. Hemenway, N. Kaminski, and M. Rincon

Rapid Lymphocyte Recruitment and Induction of the Lymphocyte Chemokine Ccl17 after Epithelial Hyperplasia in Mouse Lung. J. W. Tichelaar, H. Yin, S. Chowdhury, N. L. Harris, and M. T. Borchers

Mice Deficient for LSC, a Gene Involved in Leukocyte Migration and Adhesion, Exhibit Lung Pathology Similar to Human Emphysema. J. M. Hartney, J. Brown, J. Hu, L.-Y. Chang, R. P. Bowler, and R. M. Torres

Lung Interstitial Dendritic Cells Initiate Granuloma Formation Induced by Particulate Antigen by Priming Naïve Cd4 T Cells in the Mediastinal Lymph Nodes. H. J. de Heer, H. Hammad, T. Soullié, S. Jung, M. A. M. Willart, L. van Rijt, B. N. Lambrecht, and H. C. Hoogsteden

A New Model of Airway Transplantation to Evaluate Early Inflammatory Events, Fibroproliferation and Epithelial-Mesenchymal Transformation (EMT). A. Babu, T. Murakawa, M. Zamora, F. Grover, M. Kerklo, and M. Nicolls

Single Nucleotide Polymorphism Haplotypes in the Bactericidal/Permeability Increasing Protein Gene Influences the Risk of Developing Rapid Airflow Decline after Hematopoietic Cell Transplantation. J. W. Chien, L. P. Zhao, J. A. Hansen, W. H. Fan, T. Parimon, and J. G. Clark

The Antisynthetase Syndrome: An Under-recognized Etiology of Interstitial Lung Disease. S. K. Danoff, L. Christopher-Stine, and M. R. Horton

Tirap Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella Pneumonia but not Pseudomonas Aeruginosa. S. Jeyaseelan, S. K. Young, M. Yamamoto, S. Akira, J. K. Kolls, and G. S. Worthen

IL-23 and IL-17 Mediate Airspace Inflammation in a Chronic Model of Mucoid Pseudomonas Aeruginosa Pulmonary Infection. P. J. Dubin, L. Ulrich, T. Dubowski, N. Ghilardi, and J. K. Kolls

Chemokine Regulation of Macrophage Apoptosis and Dendritic Cell Traffic. M. H. Grayson, E. Y. Kim, and M. J. Holtzman

Mutant P53 Expression in the Lung Epithelium Causes Dose-dependent Modulation of Interstitial Lung Disease Progression Initiated by Transforming Growth Factor ß-Expressing Adenovirus. G. F. Morris, A. Notwick, D. A. Pociask, and A. R. Brody

Plified Immune and Fibrotic Responses in Hermansky Pudlak Mice. L. Young, M. T. Borchers, R. Pasula, and F. X. McCormack

Toll-Like Receptor Expression and Cytokine Secretion after In Vitro Stimulation of Lung and Blood Cells in Sarcoidosis. M. Wikén, J. Grunewald, and A. Eklund, J. Wahlström

IL-4 mRNA Stability Is Mediated by RNA-Binding Protein Hur. T. O. Yarovinsky, N. S. Butler, M. P. Mohning, M. M. Monick, and G. W. Hunninghake

Genetic Predisposition to Sarcoidosis Uveitis: Role of Heat-Shock Proteins 70 (Hsp70) Genetic Polymorphisms. P. Spagnolo, H. Sato, S. E. Marshall, A. U. Wells, K. M. Antoniou, R. M. du Bois, and K. I. Welsh

HLA-DQB1*0602 Allele Is Associated with Splenomegaly in Japanese Sarcoidosis. H. Sato, S. Nagai, T. Handa, Y. Suginoshita, K. Ohta, K. I. Welsh, R. M. du Bois, T. Izumi

RSV Activates Mdm2 Causing Decreased P53 Protein Followed by Type 1 Interferon-Mediated Recovery of P53 in Airway Epithelial Cells. D. Groskreutz, M. M. Monick, L. Powers, T. O. Yarovinsky, and G. W. Hunninghake

A Role for Reactive Oxygen Species in Beryllium-Induced Lymphocyte Proliferation. A. P. Fontenot, R. T. Sawyer, D. R. Dobis, G. B. Pott, L. A. Maier, L. S. Newman, B. J. Day

Cigarette Smoke Extract Suppresses Maturation-Associated Dendritic Cell Interleukin-12 Production through Oxidative Stress. P. R. Kroening and R. Vassallo

A Murine Model of Pulmonary Fibrosis Using Chronic Exposure to Bacillus Subtilis. P. L. Simonian, C. L. Roark, R. L. O'Brien, and A. P. Fontenot

Immune Recognition of Mycobacterium ESAT-6 Antigens Is Associated with HLA-DRB1*1101 in Systemic Sarcoidosis. W. P. Drake, M. S. Dhason, H. Sato, B. E. Shepherd, S. Vivedulu, R. Hajizadeh, L. S. Newman, S. A. Kalams

Pulmonary Granulomatous Inflammation in Response to Mycobacterial Catalase-Peroxidase Protein: An Experimental Model of Sarcoidosis. E. S. Chen, Y. Zhang, and D. R. Moller

Long-Term Depletion of B Cells Is an Effective and Safe Treatment Option for Patients with Chronically Relapsing Wegener's Granulomatosis. J. M. Golbin, K. A. Keogh, F. C. Fervenza, S. R. Ytterberg, and U. Specks

Novel Interactions between TGFß and Serum Response Factor Networks: Implications for Asthma. B. Camoretti-Mercado, J. Churchill, S. Dewndara, C. G. Lee, J. A. Elias, and J. Solway

NKG2D Ligands in the Development of COPD. M. T. Borchers, N. L. Harris, J. W. Tichelaar, K. Fogel, and D. McGraw

POSTERS

Cigarette Smoking Modulates T Cell Responses in Lung and Mesenteric Lymph Nodes. A. A. Frazer-Abel, S. Lazis, J. Harvey, and B. M. Freed

Inflammation in Pulmonary Vascular Remodeling. G. Grunig, E. Grunig, E. Daley, K. Robinson, V. P. Kurup, C. Hogaboam, P. Lincoln, L. Taraseviciene-Stewart, and N. F. Voelkel

Lymphocyte Mediated Inflammation in a Murine Lung Injury Repair Model. P.L. Simonian, F. Diaz del Valle, A. Fontenot, N. F. Voelkel, I. S. Douglas

Immune Recognition of Mycobacterial Antigen 85a by Sarcoidosis Peripheral Blood Mononuclear Cells. W. P. Drake, R. Hajizadeh, J. Carlisle, M. T. Nadaf, B. E. Shepherd, and S. A. Kalams

Beryllium-Induced TNF- Production Is Transcription-Dependent in Beryllium Disease. B. C. Tooker, R. T. Sawyer, A. P. Fontenot, T. A. Barnes, C. E. Parsons, L. A. Maier, M. M. Gillespie, E. B. Gottschall, L. Silveira, J. Hagman, and L. S. Newman

The IL-13r2 Receptor Attenuates Lung Injury and Remodeling. J. A. Belperio, H. Nakamura, Y. Y. Xue, J. Pan, M. D. Burdick, R. M. Strieter, and M. P. Keane

Pseudomonas Modulates TNF- Induced Kupffer Cell Inflammation and Apoptosis. A. Ashare, T. Yarovinsky, L. S. Powers, M. M. Monick, and G. W. Hunninghake

Functional and Phenotypic Characterization of CD57+ CD4+ T Cells and Their Association with Chronic Beryllium Disease. B. E. Palmer, D. Mack, A. Martin, and A. P. Fontenotand A. P. Fontenot

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