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The Proceedings of the American Thoracic Society 5:283-284 (2008)
© 2008 The American Thoracic Society
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Erratum: Future Treatment to Lessen Exacerbations of Chronic Obstructive Pulmonary Disease

Alan R. Leff, Editor

From the Editor:

Because of an oversight in the correction of the article at proof stage, there were several errors in the publication of the Lund Symposium article "Future Treatment to Lessen Exacerbations of Chronic Obstructive Pulmonary Disease," which appeared in the December 2007 issue of the Proceedings (1).

Most of these errors involved the interchange of the words avidity and affinity in the text. On the first page of the article, right-hand column, the sentence beginning on line 19 of the paragraph under the heading PATHOGENESIS OF NEUTROPHILIC INFLAMMATION should read "Upregulation of β2-integrin (CD11b/CD18) in PMNs requires a conformational change/affinity in this integrin ...." Similar errors also appear in Table 1 and in the Figure 1 image and legend (reprinted below for the convenience of our readers).


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  		TABLE 1. REQUIREMENTS FOR β2-INTEGRIN LIGATION

 

Figure 1
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  		Figure 1. (A) β2-Integrin activation for adhesion. Top: Up-regulation of cell surface CD11b expression. Middle: Conformational change/affinity of CD11b. Bottom: Focal clustering/avidity of CD11b to amplify "stickiness" while rolling. (B) Localization of CD11b on the eosinophil surface. Naive eosinophils were transduced with HIV-TAT–dominant negative Ras protein (TAT-dnRas) before activation with IL-5, eotaxin, N-formyl-methionine-leucine-phenylalanine (fMLP), or phorbol myristate acetate (PMA). Note that CD11b is dispersed for cells treated with TAT-dnRas; PMA, which bypasses the Ras pathway, is not affected by TAT-dnRas. Reproduced by permission from References 11 (A) and 18 (B).

 
Finally, Reference 11 is incorrect; the correct citation should read: "van Kooyk Y, Figdor CG. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr Opinion Cell Biol 2000;12:542–554."

REFERENCES

  1. Leff AR, Muñoz NM. Future treatment to lessen exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2007;4:659–666.[Abstract/Free Full Text]




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