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The Proceedings of the American Thoracic Society 5:360-361 (2008)
© 2008 The American Thoracic Society
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Loss of MMP-13 Delays Inflammatory Response after Acute Hyperoxic Lung Injury

Anita I. Sen1, Robert F. Foronjy2, Takayuki Shiomi2 and Jeanine M. D'Armiento2

1 Department of Pediatrics, and 2 Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York

Correspondence and requests for reprints should be addressed to Anita I. Sen, M.D., Department of Pediatrics, Division of Critical Care Medicine, Columbia University, College of Physicians and Surgeons, Morgan Stanley Children's Hospital of New York–Presbyterian, 3959 Broadway, CHN 10-24, New York, NY 10032. E-mail: ais13{at}columbia.edu

Studies in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) have shown that matrix metalloproteinases (MMPs) play an important role in this pathological process. We have recently demonstrated that MMP-13 is an important mediator of inflammation in fibrosis of the liver after acute injury. The function of MMP-13 in ALI, however, is unknown. To evaluate the role of MMP-13 in ALI, this study examined the effect of hyperoxic lung injury in wild-type and MMP-13–deficient (KO) mice. Mice were studied under various hyperoxic conditions: after 3 days of treatment with 85% oxygen, after 5 days of treatment with 85% oxygen, and after 6 days of treatment with 85% oxygen, followed by 7 days of recovery. There was no difference in average length of survival between the KO and wild-type mice under all conditions. After ALI (i.e., 3 d of oxygen) histologic demonstration of intra-alveolar hemorrhage was delayed in the lungs of the KO mice when compared with the wild-type mice. After recovery from ALI (i.e., 6 d of oxygen and 7 d of rest), the KO mice exhibit an increase in inflammatory cells within the bronchoalveolar lavage when compared with the wild-type mice. Future studies will examine this model further to better characterize the role MMP-13 in ALI.

FOOTNOTES

Supported by NIH grant RO1-JD HL086936–01 (J.D.).

Conflict of Interest Statement: None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

(Received in original form August 29, 2007; accepted in final form October 16, 2007)





This Article
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Right arrow Articles by Sen, A. I.
Right arrow Articles by D'Armiento, J. M.
PubMed
Right arrow Articles by Sen, A. I.
Right arrow Articles by D'Armiento, J. M.

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