Proceedings of the American Thoracic Society Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Proceedings of the American Thoracic Society 5:365 (2008)
© 2008 The American Thoracic Society
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by O'Cain, P.
Right arrow Articles by Quasney, M. W.
PubMed
Right arrow Articles by O'Cain, P.
Right arrow Articles by Quasney, M. W.

The Surfactant Protein B +1580 Polymorphism and Lung Injury in Children with Community-acquired Pneumonia

Peggy O'Cain1, Pallavi P. Patwari2, Melita E. Smith3, Mary K. Dahmer3 and Michael W. Quasney3

1 Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee; 2 Department of Pediatrics, Northwestern University, Chicago, Illinois; and 3 Children's Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin

Correspondence and requests for reprints should be addressed to Peggy O'Cain, M.D., Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, 50 N. Dunlap, Memphis, TN 38102. E-mail: pocain{at}aol.com

Surfactant protein B (SP-B) is an integral part of surfactant at the alveolar air–epithelial interface and is important in reducing surface tension. The SP-B+1580 T to C polymorphism within the gene coding for the SP-B results in an amino acid change that appears to influence SP-B function and has been shown to be associated with more severe lung injury in adults with community-acquired pneumonia (CAP). We tested the hypothesis that the SP-B+1580 CC and CT genotypes are associated with more severe lung injury in children with CAP.

Discarded blood samples were obtained from children with CAP who had a complete blood count as part of their workup. Genotypes were determined and did not deviate from Hardy-Weinberg equilibrium. Genotypic frequencies of children who required mechanical ventilation (MV) were compared with those who did not require MV. Statistical analysis was performed using Chi square analysis.

Six hundred fifty-two children with CAP were enrolled. The frequencies of the SP-B+1580 polymorphic site in both those children requiring MV and those not requiring MV are shown below (Table 1). The frequency of MV in those children with CAP with the CC or CT genotypes was greater than that in children with CAP who were TT (0.157 versus 0.067; P < 0.0005).


View this table:
[in this window]
[in a new window]

  		TABLE 1. GENOTYPIC FREQUENCIES OF SP-B +1580 POLYMORPHISM IN MECHANICALLY VENTILATED VERSUS NON–MECHANICALLY VENTILATED PATIENTS

 
There is a higher frequency of MV in those children with CAP who have the CC and CT genotypes, suggesting that the C allele may be used as a marker for the increased likelihood of more severe lung injury. These results also suggest that patients with the C allele may benefit from more targeted therapy.

FOOTNOTES

Supported by R21HD047670-01 (M.W.Q.) and the Children's Research Institute.

Conflict of Interest Statement: None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

(Received in original form November 16, 2007; accepted in final form November 30, 2007)





This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by O'Cain, P.
Right arrow Articles by Quasney, M. W.
PubMed
Right arrow Articles by O'Cain, P.
Right arrow Articles by Quasney, M. W.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS