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About the cover: Illustration shows nutlin-2 binding to the p53 pocket of MDM2 (side chains of Phe 19, Trp 23, and Leu 26). Reprinted by permission from Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filiporic C, Kong M, Kammlot U, Lukas C, Klein C, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MOM 2. Science 2004:303:844–848. For more information see article by Ciechanover beginning on page 21.