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About the cover: Cover is based on a photomicrograph depicting the migration of a population of predominatly acute inflammatory cells migrating through the airway epithelium of a guinea pig in response to an acute exposure to tobacco smoke inhalation. Modified by permission from JC Hogg: Pathophysiology of airflow limitation in chronic obstructive pulmonary disease (Lancet 2004;364:709–721). For more information, see article by Curtis and colleagues, beginning on page 512.
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