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About the cover: Cover is based on an intravascular ultrasound image demonstrating the pre-treatment extent of atherosclerosis in a patient enrolled in the ASTEROID trial. The outer border of the superimposed colored region indicates the external elastic membrane, the colored region indicates the atheroma area, and the inner uncolored region indicates the lumen area. Reprinted by permission from S.E. Nissen et al.: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis (JAMA 2006;295:1556-1565). For more information, see article by Luppi and colleagues, beginning on page 848.
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